Preclinical

Expertise

Assessment of properties and performance of regenerative and restorative dental biomaterials on different in vivo models

Biocompatibility/ biodegradability :

- Subcutaneous implantation inflammatory and foreign-body reaction

- Biodegradation patterns of biomaterials

Regenerative biomaterials performance :

- Osteogenesis

- Osteoconduction / osteoinduction

- Volumetric analyses

- Critical size defect models  

Peri-implant hard and soft tissue integration :

- Osseointegration/bone to implant contact

- Epithelial and connective adhesion/attachment on implant component

Facilities and equipments

Animal facilities :

• Ethical committee for animal use and care
• Mouse, rat, rabbit and minipig models

Bioinformatics and Imaging :

• Histometry and histomorphometry
• Histologic data sharing platform (Cytomine)
• Ex vivo MicroCT scan
• 3D modeling

Histology :

• State-of-the-art non-decalcified histology
• Routine paraffin processing and sectioning
• Immunohistology and histochemistry capabilities